I've driven V12's from Aston, BMW, and Mercedes, absolutely beautifully smooth in their operation. The 4.6 V8 in my GX460 is also a very nice engine in regards to NVH.That's physics, an inline 6 has primary and secondary balance. I've seen over the years people trying to argue a V6 is as smooth or smoother--I always wondered do they have both in their garage to compare, or just making that up? lol
My LS is a 4.3 V8, it's silky smooth, despite not having primary balance, they are inherently balanced. I've never owned a V12 to compare--that would have primary balance.