There are plenty of folks over in the By-Pass Filtration Forum that have over 50,000 miles on their oil and it's still above 1.0 on TBN (with make-up oil at filter changes), and they are doing fine.
But it depends on a lot of things going right. NEVER a coolant leak into the engine, ever. Starting with really good oil like AmsOil or Pennz Platinum or Redline, etc. By their nature, these are cautious folks who check things a LOT. And they have spent $$ on UOA's...
To me, it's all a trade-off ... State of Cali Fleet Admin did studies in the late 1990's on their fleet of over 25,000 cars and light trucks and determined that the best trade-off point was 6,000 mile oil changes with filter changes at 12,000 miles. Vehicles were expected to last out to 200,000+, and then go to auction.
I drove my state truck to 258,000 following this schedule. It was still running like a top. But, at 150,000 or so, I switched it to HDEO 15W-40 because of the noises it was making (timing chains) on the dyno at biannual SMOG test time. Couldn't hear it in the cab, but standing in front of it under load it was pretty miserable.
Point being, you should not ever shoot for clean, clean,clean. You will spend more money on oil, filters, additives and gadgets, than just being prudent and seeing about a rebuild at 250,000.
They'll boil the block and heads then, so all the varnish and any sludge that might be there will be gone. You just want to get there in one piece with reasonable gas mileage and minimal oil consumption