I've been asking myslef this for the past quarter century or so.
Based upon my results, I'd say there's no difference in either engine life or fuel consumption, although I'd like to think that synthetics are the better oil.
Long drains?
We have a mod who went 10K on an old Nissan V-6 and had a great UOA using Walmart's pride conventional.
Bottom line is that Quaker State Ultimate Durability is (or was) a Dexos 1 licensed oil.
It is pretty cheap at around twenty bucks a jug from Walmart.
If you want to use synthetic, there you go.
I doubt that the avaerage Dexos 1 compliant syn blend is much, if any cheaper.