We have a 2000 Sienna still running well with 240,000 km, no major issues. Some minor electrical problems with power window switches, heater temperature dial and headlight switch. I changed the battery for the first time last year. Front brakes have been replaced twice.
All major mechanical including Motor, tranny, starter, alternator, exhaust, cv joints, wheel bearings, power steering pump, radiator, water pump, air conditioning system, shocks and struts are all original.
But, I also love my 1994 Honda Accord which is also still going strong with very few problems.