Originally Posted By: antiqueshell
Originally Posted By: Big_Kat
Originally Posted By: buickman50401
This thread just keeps giving and giving.
It sure does, I think I'm going to stop posting on it.
Too much tinfoil...
Esoteric translation....sheeple, do not even THINK about other possibilities, especially the one where the so called "experts" are flat out WRONG, as they often times are. Go back to taking that rat poison, drinking that fluoridated water, and watching the mindless sports every night in front of the boob tube.
One I don't watch sports, two switching from well water to city water in the 1950s probably saved my fathers life, and three have any of you looked up the requirements to become a water treatment plant tech? I believe are state requires 6 months of experiences shadowing before you can be certified by the DNR. Also I go back on my stance that the OVERALL LIFE EXPECTANCY in the USA has been rising since the 1960's. GO back to the 16th century and try getting help when you have a stroke, or get a virus.
Give this a read:
http://www.oralhealthgroup.com/news/paed...ide/1000118049/
FLUORIDE ACCUMULATION IN THE PLAQUE AND THE BACTERIAL CELL
Dental pellicle is formed as a result of the strong affinity of salivary proteins and glycoproteins for tooth surface. These proteins form a layer of pellicle that is poorly organized and is free of bacteria. Further deposition of salivary constituents, food debris, and inorganic compounds strengthen the structure of dental pellicle. This provides a matrix to which microorganisms become attached and release their products into the resultant meshwork. The resultant porous and non-calcified coating on the tooth surface is known as the dental plaque and it harbors oral microorganisms (Anusavice, 1996; Rose and Turner, 1998).
Fluoride application to the porous matrix of dental plaque results in its accumulation (Tatevossian, 1990; Iwami et al., 1995; Spets-Happonen et al., 1998). It has been demonstrated that after rinsing with a chlorohexidine gluconate-sodium fluoride-strontium (CXFSr) solution twice a day for two weeks, the fluoride and strontium content of the plaque remained high for at least three weeks after completion of rinsing (Spets-Happonen et al., 1998). Plaque fluoride accumulates in two pools. Most of it (95%) exists as bound fluoride either inside the bacterial cells or attached to the matrix of the plaque, whereas the remaining 5% is present in the plaque fluid as a free ion (Fig. 4) (Tatevossian, 1990).
Oral bacteria growing in the presence of fluoride accumulates fluoride (Jenkins and Edgar, 1977). The amount taken up by the cells is proportional to the fluoride level in the external fluid phase. Fluoride accumulation in Mutans streptococci occurs due to a concentration gradient of fluoride across the membrane and does not involve an active transport mechanism (Kashet and Rodriguez, 1976; Whitford et al., 1977).
A decrease in external pH, indicating a more acidic environment, also leads to an increase in fluoride accumulation (Whitford et al., 1977). This leads to the conclusion that fluoride was taken up into the cell as hydrogen fluoride (HF) (Fig. 4). A fall in the extra-cellular pH results in the accumulation of more fluoride by the bacterial cell in an attempt to neutralize the acidic environment. The important relationship between the change of pH and fluoride uptake, is known as "F/pH effect", and has been confirmed by other workers (Eisenberg and Marquis, 1980; Vicaretti et al., 1984; Kashket and Preman, 1985).
Subsequent to the transfer of HF across the membrane into the bacterial cell, the more alkaline intracellular compartment results in the dissociation of HF to fluoride and hydrogen ions (Hamilton, 1990). As a result, the continued influx of fluoride and concomitant build up of intracellular protons (H+) acidifies the cytoplasm (Fig. 4) (Guha-Chowdhury et al., 1997).
EFFECT OF FLUORIDE ON THE HOMEOSTATIC PATHWAYS OF THE CARIOGENIC BACTERIA
Accumulation of intracellular protons reduces the intra-cellular pH below the pH threshold for both catabolic and biosynthetic enzymes (Hamilton, 1986). In this way, therefore, fluoride increases the acquisition of protons by cells and results in a reduction in the tolerance of oral bacteria to growth and metabolism in acidic environments (Bender et al., 1986; Bowden, 1990; Spets-Happonen et al., 1998).
So basically the bacteria up take the fluoride to a higher concentration of fluoride outside the cell, active transport is not needed. This up take in the cell causes a pH change causing the bio-molecular pathways and enzymes to quit working, thus killing the organism.
