The manuals for my 1974 OMC sleds give you an option to run motor oil in lieu of 2 stroke oil. They change the ratio from 50:1 to something around 24:1. But if i recall, it was more for emergency use only.
Fifty years ago 20w and 30w oil was recommended by two stroke engine makers including Lawn Boy. A little later Lawn Boy came out with their own oil that was an improvement but not by much. One of the biggest problems with the xxW and Lawn Boy oil was hard carbon. Hard carbon caused the death of many two stroke engines including Lawn Boy engines from seized rings to scored pistons and cylinders.