I don't think it will hurt the rubber that is used these days, but I did try small amounts of acetone for a good while a number of years ago after reading about "miraculous" results. I had none of them, but I wasn't using a whole bottle.
There is already small amounts of it in your gas along with other chemicals similar to acetone so it won't hurt a thing. Old wives tails still alive and strong in here... guess you guys still think race gas will burn yer pistons!!
i have experimented using acetone about 3 oz per 10 gallon of fuel along with other additives such as mmo, tcw3, lucas fuel treatment, a host of fuel injector cleaners and etc off and on for some time and to date i have experienced no problems in any of my 5 vehicles and small engines that i have run it through.
acetone is also supposed to be in gasoline but I do not know exactly how much.
come to think of it this way: we use Acetone to dissolve epoxy, so you can be absolutely certain that it will break down elastomers, such as seals, o-rings, given sufficient exposure and concentration.