I had never driven one before I bought my MG(1970 MGB).
I handed over the cash, signed the papers, and hopped in the car to drive it home(~60 miles).
I bucked it, squealed the tires, and stalled it plenty of times on the trip home, but I made it. I went straight to work, and then ended up driving home that evening in a rain storm(there wasn't a top frame even installed in the car at the time-the co-worker who drove me up to get the car took it home in his car) and out of the three wipers on the car there was only one that was sort of functional. I ended up driving with my glasses off and looking over the top of the windshield just to see where I was going.
In any case, the car wasn't bought as a main car, and never has been for me. It didn't take me too long for it to become second nature, though-the key was just getting out and driving it. Learning about ignition timing and actually getting it set more or less correctly so that I didn't have to rev it to 2500 rpms to get torque helped a lot on hill starts also
. I don't deny running a few red lights, though, when I was still learning(of course making sure things were clear) to avoid a hill start.