I know cats don't like zinc ( from what I have been told ) but would one oil change with high zinc during break-in hurt them ? Has anyone ever had a cat poisoned using a high zinc oil?
Personally, I do like to get the break-in oil out early in everything. I also like the idea of using Mineral base or simi synthetic until its broken in if not always but thats just me.
With my new 2023 Harley I did change out the break-in oil at 100 miles as like you OP I wanted a high Zinc oil so I used a very high zinc mineral oil but I also installed a new NO CAT head pipe so I have NO cat for zinc to damage.
If It was my F250, I would simply change it at 500 or 1K at my local Ford dealer with a Factory Motorcraft filter with simi-synthetic Motorcraft oil and then get on a regular rotation and perhaps go full synthetic after break-in or perhaps not as I love my local Ford service and I have had great luck using Motorcraft simi synthetic.
I know Mobil 1 has many fans and some haters but I owned a then almost new 4.6L Ford Crown Vic and changed to Mobil 1 oil and Mobil 1 filter at 16K miles and thats what I used moving forward and it being a low milage car I changed the oil and filter often about every 3,500 miles and then sold the car a few years later with only 54,000 miles.
At around 50K the valve seats I guess were leaking as I would get a puff of blue smoke at start up. Not blaming Mobil 1 but that never felt right with me. I have now owned 7 used Crown vics, most retired Police cars ( I buy and sell them for fun ) some with 145K + miles and I never seen a puff of blue smoke again and I always just used Motorcraft simi- synthetic.
I had a slightly modded 1997 Harley I purchased new that I decided to change from mineral oil to Mobil 1 V-twin Synthetic, I put about 15 miles on it and developed a top end tick, drove it back home dumped that "ticking " Mobil 1 synthetic out, refilled with mineral oil and now 25 years later and 40+ mineral oil changes I have never had another tick.
So, simply based on MY life experience I would do one early oil change and stick with Ford service / oil / filter... I have had great results and my local Ford dealer recently started offering come to me service and a 1/2 off promo.
Me being able to watch a Ford tech change my oil in my driveway with Ford oil and filter for less than I can buy it myself while I sit on the porch and watch in the shade...
Its a easy choice for me