I used to do the techron thing around each oil change ( 5k/6 mo). Worked Well for my Fall OC, as we'd visit my brother in Dallas every October, and I would Run plenty of fuel though on that trip,(1100mi ea way, 2-3 Fuel stops, ~2 Full tanks), and I'd Change the oil after I got back.
then he moved back home. ...no more guaranteed fall trip.
Nowadays... i put in a 1/4 tank of E85 a couple times a year, and I'm using Top Tier fuel almost exclusively.