How much of a difference does a 200 yard vs. 300 yard zero make in the point of impact of a round fired down the longest hallway in your house? Is it even an inch?So what would be the alternative here? Not zeroing in your rifle? I fail to see the problem with doing this. If anything not properly sighting in your weapon and knowing your zero/effective range would be the unpractical choice.
My point, which you seem to have missed, is that there’s essentially never a justifiable outdoor defensive rifle shot for civilians. The OP titled the thread “defensive rifle” but if you’re shooting someone defensively it will undoubtedly be indoors. Shoot a guy 200 yards away and you’re going to prison.
If it’s truly a defensive rifle you should sight it in for the longest unobstructed distance in your house.