Unless you have a serious blowby problem I wouldn't think that any harmful amount of freed contaminants would make their way from your combustion chamber to your crankcase. The only thing I would suggest is making sure you get your engine up to operating temperature and keeping it there to maximize the cleaning. If you have a long commute or put a lot of highway miles on your car, that's all you need. But if you're a short tripper like me, maybe add in a few highway runs on the tank with the fuel system cleaner.