Illinois and Iowa have had bio of at least 10% at the pumps for quite a few years now. Seems like just about every major truckstop across the entire midwest has bio at some level now, up to 15% in some places. To that end, some bio has been going into my last semi for the last 3 years I owned it, and my present one since I bought it 2 years ago. So for at least 5 years straight it has been a part of the fuel that has gone into my truck, I haven't ever had any problems with it except a few more filter changes in the coldest weather. And with a Davco filter unit, a filter change is a pretty simple proposition.
Would be curious what "ton of issues" you have had. What engine you running it in. I have used it in a Cummins ISX and the factory rebuilt Series 60 in my FL glider kit truck.