What year is your RX. There was a TSB back spec'ing 5w20. I am running 0w20 Toyota brand oil in my 2006 400h which is the same 3mzfe motor as in the 330, but detuned for the hybrid system. My contact at the Toyota dealership confirmed that 0w20 was back spec'd to run in my vehicle. I cannot see any reason you couldn't run a 5 or 0 at one end with the 20 on the other.