My Uncle is a sales rep for various hardware/and plumbing lines, doesn't do quite the miles you are talking about, (maybe 30k mi/year) His last few cars, all but one purchased new:
1995 Pontiac Bonneville SSEI 275k mi in 10 years, demoted in 05 to spare car status.(Cash for Clunker'd w/ around 300k mi)
2006 Lincoln Zephyr* 90k miles in 3 years demoted to second car, Sold off summer 2014
2009 Huyndai Tuscon (bought with C4C money)traded in 2 years later
2011 Lincoln MKX(Purchased used, w/75k mi. traded in @150k mi)
2013 Lincoln MKX still driving, unk mi, but considering trading in.
*Lincoln Zephyr, Fancy Fusion, single year model, 2007 renamed MKZ refreshed design, and powertrain(replaced duratech 3.0/asin 6 speed, with 3.5 cyclone/ford 6f.)