The 2008-2010 Siennas are the second (previous) generation. The second generation is what I own, it has been VERY reliable and durable. They only used a V/6 engine in the second generation.
DO NOT buy a 4-cylinder in a third generation 2011-2012 Sienna! I rented one for a week. The van is too heavy and WAY underpowered with a 4-cylinder. Not only that, they don't get any better gas mileage than the V/6 because the poor little engine has to work so hard. Having said that, you can get a deal on one with the 4-cylinder because nobody wants them.
The 4-cylinder Sienna has the same power-to-weight ratio as the Transit Connect. It also has the same amount of power as the 3.8L pushrod V6 used in the Caravan of the time. It might have sold better if Toyota made an effort towards the commercial market; a 4-cylinder minivan would be great for business/fleet use. 2.7L isn't exactly tiny, either.
Most importantly, most minivans are impossible to work on. The 4-cylinder Sienna is one of the rare exceptions. You can actually see the entire engine under the hood!