As for the emissions stuff, there is no "clean" fuel available. Ethanol has its issues, most times, folks zero in on various aldehyde formations, but gasoline has a laundry list of known carcinogens that get emitted. And the concentrations make a difference as to whether a particular component is really all that dangerous.
To the original question, if a substantially older vehicle has not ever used E10, and one still has straight gas available, it might be a good thing to just keep on using straight gas if it is available. The ethanol will loosen up any buildup in the fuel system and could cause a few frequent filter changes or something a little more difficult. A '88 vehicle would have no problem if it had E10 frequently since it's build. I ran vehicles just fine in the late 70's / early 80's on E10 without ever seeing any issues. And many of my neighbors, the same.
Energy level of the fuel does not necessarily equate to lower fuel economy. To be fair, ethanol will show some mpg loss in most gasoline engines, primarily because their timing, compression, and other characteristics are set for gasoline and not for ethanol. There are several engines in development now, that have power outputs comparable to diesels, especially torque levels of diesels at lower RPM's than most production gas engines. at half the displacement of diesels, with mpg numbers a little higher than gasoline. And they do it on E85. There are many characteristics that make ethanol, especially E85 at the pump, a better fuel from a working or high performance engine, that gasoline at the pump can't even come close to matching. But to garner the benefits, the engine has to be designed primarily for it. On E85, it is proven that the proper engine design, a 2.8L E85 engine can produce more torque than most NA 5L-6L gas engines, and they can reach 90% of available torque at around 1800 RPM and peak at only 2800 RPM, and hold peak torque longer on up the RPM band. Most V8 gas engines don't even reach peak torque till way on up the RPM band, most not till they get around 4000 RPM or more.