I have used VP Racing 2 cycle oil at 50:1, 45:1, and 40:1 on Stihl (4 mix and 2 cycle models), Redmax, old Lawnboy/Toro-Suzuki 2 cycle walk behind mowers and a few cheap chain saw equipment. I use ethanol free (REC89) fuel on all my 2 cycle/4-mix equipment. I experiment with the different fuel to oil ratios from time to time but mostly/recently use 45:1. I cannot detect any engine performance changes at the different ratios. Suspect the real test is internal engine wear at elevated hours. No exhaust smoke at 40:1. My current 45:1 adds a margin of safety in case I did not mix the fuel myself (some friends/kids suggest I have trust issues).
Some of my Redmax line trimmers, blade edgers, and handheld/large backpack blowers are over 24 years old. Before VP oil, I used Redmax FD oil. This year I had to replace a cylinder to case gasket on a 24 year old redmax hand held blower (my guess over 800 hours use in OAT range from 95F to 10F -winter use clearing cars of snow) so I got to inspect the internals. Very clean with no significant wear on the bore and piston.
I think the key for small hand held 2 cycle/4-mix equipment is to use an FD rated oil at a ratio between 50:1 and 40:1 mixed with fresh fuel. I like ethanol free fuel as it has almost eliminated my carb clean/rebuilds in the last 8 (estimated) years since I switched over.