The way I do it is I reset my MPG calculator by resetting my Trip to zero everytime I fill up, so I always know the ballpark MPG I should get.
When I see my MPG start to deteriorate beyond my norm, I dump in a bottle of Gumout Fuel Injection Cleaner that I stock up on when it is on sale.
That usually fully restores my MPG as Montreal fuel is filthy and clogs the injectors.
If your injectors aren't atomizing properly, kiss your MPG goodbye.
Then before each oil change, I nail the car first with a bottle of Gumout FI Cleaner again, then a bottle of Gumout Regane High Mileage on the second tank. Third tank is untreated, then I do an oil change.
That is about all you can really do effectively with additives.