I like "The Car Care Nut" even for non Toyota/Lexus vehicles. I agree with him on many fronts and I have indeed taken a vehicle to 300,000 miles(actually 340K miles/18 years) but, it wasn't easy living here in the North East.
Alternator, Gas Tank & Radiator were the largest parts that I had to replace along with the occasional brakes, suspension & exhaust parts. Finally the rust from winter road salt took its toll on the chassis causing the car to be unsafe to drive. I had another 2 cars that were in similar situations but with only ~170K-200K miles(16 & 17 yrs respectively) but here too, the road salt got to their chassis as well.
I believe that if I lived in an area that didn't experience winter, I could keep my vehicles much longer with fewer issues/replacement parts. Especially if I had that known/reputable reliable vehicle, live in a warmer climate and the car has me for an owner, who knows how far it could go?
I realize that in the south & PNW that there is such thing as (((HEAT))) and sun damage but, I would also keep the vehicle garaged whenever possible.