It's been a long time, (1977) that I took 80 to go from Pittsburgh to Harrisburg. That was a big mistake. The scenery was beautiful, especially in one farm section with such a nice view that I just had to pull off to the side and get out and spend a few more minutes taking it in, instead of just passing through. Who ever owned the farm house there has one of the nicest views in the entire country. But 80 is a truck road with way too many heavy trucks taking it to avoid tolls. Way too many hills, and busted up roads from the heavy trucks. Like riding a bucking bronco for way too long. I never took that road again. Probably used more extra gas than the cost of the turnpike toll, took longer, requires much more driving attention, and in general not a present drive at all. The only up-side is the beautiful scenery in a few locations. Maybe nice to see once, but if 80 is as bad as it was back then, it is not worth driving it twice.
Just my humble opinion of 80