Yup, I have no major concerns...been using them for over 20 years without incident. My Ferrari and BMW M550iX are continously connected also, so is my motorcycle with lithium battery. My Ferrari has a battery tender connection from the factory, it came with a Ctek, though I use a Battery Minder instead. My BMW M550iX calls out where to connect a battery tender in the owners manual, so they are aware customers use them. One cannot assume, but there may infact be protection from voltage spikes if manufacturers know and even provide battery tenders with the cars.
One thing I have seen is the battery tenders fail electronically and melt/smoke...seen a couple examples online and a post on a Ferrari forum. For that reason, I have mine wall mounted, not on the car floor. My garage has a smoke alarm and two fire extinguishers, one is Halon.
In the universe of possibilities, any number of things can and will fail. Everyone has to figure out their risk level. I've had friends have car batteries explode, engines catch fire, etc...stuff happens. Make sure you are prepared and insured.