For what it's worth, I internally "traded" my 2006 Ford F-150 4x4 at work for a 2008 Dodge Ram 1500 4x4. The Ford was an extended cab with the rear suicide doors, but the Dodge is a full 4-door cab. Differences are numerous, and I'll try and enumerate them here.
The Ford has the 5.4L engine (3-valve 300 hp version I think) and 4-speed automatic. The best part I liked about this truck was the powertrain smoothness and throttle mapping. The electronic throttle would become much less sensitive when in 4-Lo. This was helpful in off-pavement situations. I also liked how you could force a 2nd gear start with the gear selector in 2nd. That pretty much concludes what I liked about this truck. I didn't think it was particularly comfortable (the seats were pretty bad), the ride was very jiggly, the bed was very jiggly, and the engine had a rather coarse sound to it. As much marketing as Ford did on the sturdiness of the F-150's frame, I'm rather unimpressed with how it rides and drives. The bed shake is very telling. The engine isn't all that peppy either, though it probably has a rather tall final drive in the axle. What really drove me nuts was the plastic surround for the floor-mounted transfer case shifter. My right shin would rest against it and begin hurting after 5 minutes in the truck. This is a huge oversight in my opinion.
The Dodge has the 4.7L, and I think it's the newer one with about 300 hp. I think it has the 545RFE. Simply put, this powertrain is leaps and bounds better than the Ford's. The exhaust note has a decided bark to it, but you can't really hear the engine in the cab unless you're above around 2000 rpm. It's also decidedly faster than the Ford, which surprised me because the engine is smaller and the truck is likely heavier (with the 4 real doors). The Dodge's 4x4 is activated electronically rather than the Ford's manual lever. I have not had a chance to use this feature yet. The sound system in the Dodge is much nicer than the one in the Ford and the cab is much quieter. The whole truck is more refined, despite both models being "base" or "work truck" models. I like the ergonomics of the Dodge's dash better, though don't really care for the Rubbermaid look to it. The Ford's dash was also hard plastic, but it looked a little nicer. The Dodge has little, if any, bed shake/rattle. It's a very tight truck.
I've always liked Ford's Modular engines, and actually never really cared for Dodge's 4.7L, but I must say that my mind has changed based on these two. The 4.7L feels like a very tight little engine, one that revs enthusiastically and responds nearly instantly. The Ford's engine, in comparison, feels rather lethargic and not very energetic.
Comments from anyone with "work truck" models of these two? To me, the Dodge clearly has the better truck. I wonder what the cost difference is, provided the same cab/bed length (seems like the Dodge has more sound-deadening materials and creature comforts).