I'd like to think that, with practice, I can ingrain manual safety release to an involuntary muscle reaction. But then I have never been in an up-close deadly confrontation and I just cannot predict how I would react in such an intensely emotional panic. The safer route, in my opinion, is to carry a gun that goes bang when you pull the trigger, period, without having to remember to do something else first.
There are lots of conflicting opinions on this subject, and to each his own; I just feel my odds are better in a panic with a DAO trigger and no manual safety. Couldn't care less how tight my groups are at 25 yards with a CCW, when it comes to self defense just go bang when I tell you to, and carry enough rounds to get me through.
Tom NJ