Ethanol has significantly less energy than typical gasoline for any given unit of measure. Ethanol averages about 75k BTUs per gallon.
https://afdc.energy.gov/files/u/publication/ethanol_basics.pdf
Straight gasoline has around 120k BTUs per gallon. (I've seen numbers as high as 125k, and as low as 115k, so I'll use the average of 120k/gal)
https://www.eia.gov/energyexplained/units-and-calculators/british-thermal-units.php
Diesel has even more energy than gasoline; about 137k BTUs per gallon.
https://www.eia.gov/energyexplained/units-and-calculators/british-thermal-units.php
Hence, pure ethanol is only about 63% as energy dense as pure gasoline. (75k is 63% of 120k)
So, if you had a gallon of E10, then 10% of that total volume would have about 1/3 less energy by volume. Hence, one tenth of the gallon would be down 35% on energy. Using E88 (which can be up to 15% ethanol), it would lose even more energy; 15% of the total volume would be down 35% of BTU energy.
Now, there are other things in typical gasoline; even things like butane (believe it or not), depending on season and location. So we'll have to just work with some broad averages here; don't nitpick and flame the nuances. Also, we should all understand that any engine could be "tuned" to maximize the specific fuel used, but we're talking about general cars which are E85 capable, and therefore can run on anything "up to" 85% ethanol. Many drag racers can "tune" engines for what they affectionately call "alcohol", which allows a MUCH higher compression ratio without fear of pre-detonation. That in turn changes the thermal performance of an engine. But we're going to stick with a "normal" engine here for my examples below. Consider an example of an E85 capable 3.5L n/a Ford Cyclone engine (in a Taurus) ...
If your car is capable of running one or more of the fuel compositions below, this is how it would play out:
If you had a 10 gallon tank of pure gas, it would be holding 1,200,000 BTUs of total energy. (our baseline reference)
If you had a 10 gallon tank of E10 (10% ethanol), it would be holding 1,155,000 BTUs of energy. (about 4% less energy by total volume)
If you had a 10 gallon tank of E88 (let's assume 15% ethanol), it would be holding 1,135,500 BTUs of energy. (about 6% less energy by total volume).
If you had a 10 gallon tank of E85 (85% ethanol), it would hold 840,000 BTUs of energy. (about 30% less energy by total volume).
If you had a 10 gallon tank of pure ethanol, it would hold 750,000 BTUs of energy. (about 37% less energy by total volume).
Using anything but pure gas will affect your efficiency (gas mileage) by an approximate degradation as shown above, all other things being held constant.