You'd have to do some serious neglect to kill the 2AZ-FE. The one in my 06 Scion tC is modified and gets abused daily, bouncing off the rev limiter in every gear, spinning the tires. 80,000 miles of this and absolutely zero issues. Still on the stock spark plugs, PCV valve, accessory belt, etc etc. Haven't touched a thing, only oil changes every 3-5k.
When shopping for a used car, i personally avoid all and ANY signs of neglect. If the engine hasn't been maintained, neither was anything else like the brakes, other fluids, and the way it was driven and treated in general.
I'd rather pay a few grand more but buy a car that was babied and driven normally. I keep my cars for many years so it's important to buy one that was taken care off and will remain that way in my hands.