My in-laws needed a car to get in/out easily. They tried an Odyssey, a Sienna, a 4Runner, and all these were sold within a year or less. Currently they settled on facelifted LS430. They liked it so much that they bought one more.
PROS: Easy to get in/out. Huge trunk. Spacious for 5 adults. Comfortable 28-30MPG on the highway, and V8 torque on demand.
CONS: a timing belt every 100k miles. Outdated, but classy interior. So reliable that it may outlast you, that's a con for people who try to ride cars until the wheels fall off...they can't with LS430.
P.S. The following LS460 is definitely a dark spot on Lexus reputation...