A lot will depend on what vehicle this is and how you maintain it. The wife's '01 Lumina (211,000 miles) is our designated road-trip vehicle; we take it on 300-mile trips up to the inlaws' pretty regularly. I just check the fluids, check over for leaks, and go. But I maintain that car religiously 'cause I don't want to be broke down in BFE Kansas on a 100-degree day with the nearest shade or human being several miles away.