2012 Toyota Prius: Got about 50mpg on a round trip to Austin (200 miles) without trying hard, going about 75mph.
2005 Mitsubishi Lancer, base engine manual 5-speed: Got about 29-30 mpg on Memorial weekend trip to the gulf. 85% highway, 15% local roads
1999 Ford Taurus with DOHC V6, 4-speed: about 20mpg, 70% highway.
2005 Ford 500 effectively the same 1990s DOHC engine, FWD 6speed auto: about 20-22mpg, 70% highway.
This makes me marvel at Toyota's technology.