Those are two very, very good questions, but I suspect they're seriously application dependent. I don't think we'll find one pure answer for everything.
For the first one, I'd suggest higher wear is unlikely unless the HDEO chosen was an extremely inappropriate grade for the gasoline engine. If it were seriously too thick (or less likely, too thin), then we might see problems. I don't think running 15w-40 in a Prius in a Saskatchewan winter would be very prudent, and with plenty of cold starts, could, at least theoretically, lead to higher wear. How significant that would be is another matter. As for more frequent oil changes, again, that depends upon the application and to which PCMO it was compared. A 15w-40 conventional HDEO may not have the extended drain capabilities of GC or M1 0w-40 in a vehicle specified for those two PCMOs. However, if you find an application where OCIs are short and the xxW-40 grade of an HDEO isn't a problem, I don't think it will matter one bit. My G uses 5w-30 (and 40 grades in other countries). Its severe service OCI is only 3750 miles. If I were to use a 15w-40 HDEO, I doubt I would have any serious viscosity issues, and the OCI is ridiculously short anyhow. Heck, it might be better for extended OCIs than certain conventional PCMOs. But, PCMOs include everything from the cheapest SuperTech to the most expensive boutiques. I can spend under $2 a litre for the cheapest conventional or over ten times that on certain synthetics.
For the second question, it's certainly possible. Some vehicles do better with enhanced ZDDP, and that's more easily attainable with an HDEO. A lot of the older vehicles have no specification issues with HDEO, either. The G specifies SM/GF-4 or better in 5w-30. That's not going to happen in HDEO. The old F-150 specifies various grades in around SJ and older. Today's PCMOs are far better than the oils of the time, and today's HDEOs are better than what was available back then, too. For the old F-150, before the rebuild, I had to run something "stouter" to combat fuel dilution over even a short OCI. The "stouter" choices were Mobil Delvac 15w-40 in the summer and MaxLife 5w-30 in the winter. 5w-30 PCMOs would see the oil pressure life flicker at operating temperatures at idle near the end of the OCI.