I’ve run 10W-60 full synthetic in my CRF250L without any issues.
Right now I’m running Motul 300V 10W-40, and I’ve been very happy with it. That said, I’ve switched all of my bikes over to Maxima motorcycle oils and the 250L will get Extra 10w-40 at its next change.
Motul 300V is over $140 for a 4-liter jug now. Maxima Extra is around $64, and ProPlus (one step below Extra, but still full synthetic) is about $43. Those are ChapMoto.com prices with free shipping over $49. It’s become my go-to place for oil.
I’ve always liked Maxima, but when 300V was around $65 a jug, I went Motul. At more than double that price? No way. I stocked up on Maxima before they possibly jack up prices like everyone else has.
Honestly, I can’t tell any difference in performance.
I run Maxima ProPlus in my cruisers (Vulcan 900 and SCR950) and Maxima Extra in my CRF250L, DR200SE, and air-cooled Vino 125 scooter. My thinking is that the higher-performance bikes deserve the small extra cost for Extra, while the low-stressed cruisers do just fine on ProPlus.
Everything gets synthetic because, why not? It helps minimize sludge and deposits while providing a little extra protection. Maxima ProPlus full synthetic is also priced almost the same as Honda GN4 conventional, so it’s an easy decision.
I’ve been riding for 40 years and have never had a lubrication-related failure. I started out running Mobil 1 15W-50, and that was excellent oil too.
I wouldn’t hesitate to run the 10W-50. Just switch back to 10W-40 or 30 at your next oil change if that’s your preferred viscosity. I’ve never experienced a failure or any negative effects from going up in viscosity.