I've never even heard of any of these engines having timing chain issues. VQ40 or 38. I was thinking and pointing fingers more at GM's "High feature" engine family
Very early on like from 2005 to like 2008? there was an issue with the guides. It would start sounding like you had a supercharger, but it was the guides failing. I had a 2007 that was definitely showing signs of it before I traded it in.