I have 4 Honda Odysseys with the J35 V-6 with VCM enabled, all speced for 5W-20. I switched all of them over to 5W-30 permanently and engines seem to run quieter. No difference at all in gas mileage. Getting 27.5 consistently on flat highways with the 5W-30.
I made the permanent switch to 5W-30 after googling HTHS wear graph. Since my vans sometimes are fully loaded with 8 passengers, heavy luggage, and go on long trips up long inclines where engine temps rise, I feel the higher HTHS gives added wear protection for severe situations.
Mixing 0W-20 and 5W-30 shouldn't be a problem. When I switched to 5W-30, I still had about 2 quarts of 5W-20 left, and I mixed them with the 5W-30 with no ill affects for the entire oil change interval.