If you are in love with the Python lock work, try finding a Colt Officer's model or early Colt Trooper. If you like large frames, the the Colt New Service would be the ticket as well as it has the famed Colt lock work. A good choice if you have large hands, not so good for double action work if your hands are small.
If you want a nice high end revolver, try the Smith Model 27. It is accurate and and has top drawer fit and finish like the Python.
If you want something styled similarly to the Python try a Smith & Wesson Model 586 or 686. Like others have said, it is robust, accurate and you don't need to worry about getting a scratch on it.