Never have done it "Scientifically" like the method described here, but i could assure that you can always feel the difference after you drive a car hard on the autobahn which was previously used mostly on short trips or around town.
4.000 RPM is my prefered cruising speed here with my Winter beater VW golf MK III. It´s a perfect smooth ride with 100 MPH / 160 KMH in 5. gear. You can drive for hours this way, the engine will last forever.
My Honda S2000 is a different story, to my knowledge it is one of the few engines wich you can destroy on the autobahn, because the engine cant stay the insane piston speed at 9.000 RPM for a longer period of time. Read: 30 Seconds ~ 1 Minute to my best knowledge.
I read about two cases in the german forum where owners blow up the engine on the Autobahn because they want to know "how fast this car can go"

They know everything about computers, but dont know the meaning of "Piston Speed" and what happens inside a engine....