Not really! They've got it all figured out that the smallest fuel tank in a car is around 10 gal's, maybe less, but no more than 21 gal's. If you have a large car/truck/minivan with a (let's say)26 - 36 gal + fuel tank, add 2 bottles at once. On a smaller tank you just get a little stronger concentration as compared to a 21 gal tank. Also on a 20-21 gal tank, you might want to add a second bottle on another tank full of fuel. I think that the directions should read i.e. "Use between 16 & 21 gallons of fuel".
Then leave it to the car owner to add more or less Gumout depending on the size of their fuel tank. Just MHO!