I don't have experience with either, but I checked Consumer Reports (I'm a subscriber) to see what they said.
The last year reviewed for the Chevy was '04. Of their sixteen reliability categories, the ones that were less than "Good", "Very Good", or "Excellent" were:
* Engine Minor (Fair)
* Electrical (Fair)
* Suspension (Poor)
* Audio System (Poor)
Everything else was rated Good, Very Good, or Excellent. Their new car prediction was "Average".
For the F-250, they have it rated through '06. And for model year '06, they rated every category as "Very Good" or "Excellent", except "Body Integrity", which was rated as "Good". In other words, they didn't rate it low ("Fair" or "Poor") in ANY category, but for some reason, they said the new car prediction was "Much Worse Than Average". I can't figure that one out, unless it's because of the earlier year problems. Specifically, the F-250 looks like it had some issues (before '06) with Transmission (a couple of Fairs and a Poor), the Drive System (five Poors and two Fairs!), and the suspension (several Fairs).
Of course this is just one company rating, but it's probably as accurate as any individual examples you may hear on a forum. Probably much less biased and scientific, too. But take it FWIW...and as always, YMMV.
Good luck!