Haha. The anti-seize discussion is endless, but here is my observation. The recommended interval for Iridium plugs is 100,000 miles. ( or that crazy 97,500 miles or so in some manuals.) So, most people will never change Iridium plugs twice in the vehicle because they would have to own the vehicles at 200,000 miles which is actually quite rare.
Very few people know what it’s like to pull plugs that have been baking in anti-seize for 100,000 miles, which might take 10 years.
But guess what. I know. I recently pulled out the first two plugs of the second set of Iridium plugs after 100,000 miles. I pulled the factory plugs around 10 years ago and put anti-seize on the second set. The product I used was Permatex #80071. It’s the silver coloured one with aluminum. There are other ones out there such as copper etc so this observation is only for Permatex #80071.
Putting anti-seize on a spark plug is not like putting it on a suspension bolt. The temperature of the combustion gas can be 2500 F and the exhaust gas can be 1000 F. What happens to the #80071? It absolutely bakes into a totally dry crumbly product. It has very little lubricity. The Iridium spark plug absolutely drags coming out and you have fight for each inch. I do not recommend it at all.
So after pulling the first two plugs, I decided to do the others later on when I have some time to deal with them. Meanwhile the truck is still running fine.
Like I said, this is only for one product. If others have an observation on another product that would be welcome, but please, no comments on pulling an anti-seize covered spark plug after 30,000 miles. It’s a totally different game after 100,000 miles.

Hope that helps.