So I got more replies than I thought I would. I was going to try and answer most of them but that seems fruitless. For those of you trying to answer my question I appreciate it, I know it is a subjective and personal thing. I should have fleshed my original query out more, but I did it last second on a whim.
I read some of the answers and was feeling myself get snarky and wanting to reply based on that but decided that will not serve me well and turn this into another thread that bitog is famous for.
So in my interest in moving this forward I will try and explain what I am after more clearly and hope I can perhaps target some choices.
First. I drive a 2017 F250 Platinum CC SRW, with the HD rear end. It is all the truck I need, not more not less (sans comfort). I cannot use a F150 in my usage scenario and I am unwilling to go dually. A 1 ton option SRW would work, but I do get all I need from a 3/4 ton.
I was not good at explaining that my issue with the truck is seat comfort on long trips. I take many long trips, I am getting older and I have back and neck issues. I know and have tried all the seat and posture setups I can possibly do on my current truck and I am just not getting to where I need to be. Ford has lowered the quality of their seats over the years and I notice it. My 2011 F350 from memory was much better. Some of my issues are just going to be nature of the beast and I know that.
So my question should have stated that I am looking for people who drive more than an hour. I am also looking for recommendations on specific trim levels. Conversely if anyone has used an aftermarket seat I would like info on that. I know that different combinations need to be tried and comfort is subjective. However it is unrealistic for me to try different trucks on long test drives. There are to many trim combinations and the length of the drive would not be granted. Different opinions could narrow my search and let me target certain trim/options from the different manufacturers.
I can point an example from my 981. Many people feel the base seat is more comfortable the the 18 way upgrade they offer. After trying both I agree and I have the base seats in my car. Admittedly I don't drive that car for hours, but my research before buying that car helped me target my options when shopping. It helped me notice things that other drivers that owned the car pointed out after longer term use.
Thanks