my best mpg gains, lube-wise, have been amsoil or castrol ATF+4 (thinnest at the time), mobil 1 in the axles, and a synthetic in the T-case (mobil 1 universal ATF is fairly thick but in a chain-driven T-case I wanted that-- it's a good fluid). I prefer mobil 1 or amsoil in the diffs. I'm NOT a mobil 1 engine oil fan at all, I've found other syns that seem to hold up longer.
Air up the tires. don't know if your 4 runner sags in the back or not, but a dropped nose tends to get slightly better hwy miles. if you have torsion springs up front, they may be adjustable to lower the front if the rear is sagging.
Tires also impact MPG. Hwy all-seasons are more efficient in general than all-terrains or heavier truck tires. Not a big michelin owner, but their LTX line is always reviewed well in every way except serious off road use.
I gotta give props to the above poster who mentioned that better flowing air filters do NOT give better MPG (in a gasser!). very few folks grasp this, but he's correct. Better flowing exhaust can, however provide small mpg gains, however too much and you can lose low-end torque and efficiency.
As to MAF and MPG.... it really depends on the vehicle. The ecu will ultimately listen to the O2 sensors as well to correct burn mix. the maf gives an immediate read and then the O2s give feedback to fine-tune. there may also be a map sensor in the loop as well, adding its opinion. To that end, IF the O2 sensor is tired, a replacement can help... but if it's OK, it's just money spent. MAP sensors give the best transient response (quickest), MAF fine tune that response over time, and the O2 gives feedback with final correction. Different cars use different or all of these systems. I wouldn't clean the MAF unless it's visibly dirty.