My vote goes for Chevron Supreme 10w40 for low-cost conventional oil. It's got tons of moly, and is a proven performer in countless used oil analysis.
If you've got the money, 5w-40 Shell Rotella T Synthetic @ about 13$/gallon at Walmart would be the best bang for the buck IMO.
To answer the above question, the high mileage oils are formulated with certain additives that help condition seals, and usually a higher viscosity. The synthetic blends are very similar to the conventional variants, with a small percentage synthetic base oil added (generally 5-10%).
What exactly are you looking for? I don't think the extra cost for semi-synthetics or high mileage oils equate to the extra performance. I'd swing for a low-cost synthetic (Rotella T), or a good conventional oil. If money is no object, Mobil 1 or Castrol Syntec 0w30 are both excellent.