I've had, and repaired for others, quite a few brands. Samsung and Asus seem to have fewer problems, but Asus doesn't sell as many so the sample size might be too small to make a fair comparison.
Personally, I'm no longer into FPS video games so don't need a very high refresh rate, and have been replacing all computer monitors with 4K TVs. Unfortunately the selection of 4K TVs in the under 42" sizes are disappearing, so it also depends on the available space. I'd do a 32" 4K monitor but don't see much point in 4K below 32" unless you've just about got your nose pressed up against the screen. Otherwise 1440p or ultrawide.
Within that context I'd get a Samsung or LG 4K TV but beware of the LCD LG's with the RGBW pixel setup, which are not true 4K and won't work well at all for a 4K computer monitor. Maybe they don't even make those today, I'm thinking back a few years.
Yes 4K is really worth it for desktop computer use. The addt'l vertical pixels are a game changer that you don't get with a multi-monitor setup unless you have one (or more) of them rotated 90' (which some people do, even with 4K displays). Gaming, depends a lot on your budget for the video card, with them being so high cost still, and along with the video card, may need case ventilation and PSU upgrade as well.