Our 2008 Honda CR-V averages about 24-25 mpg most tanks. It varies some with the weather, but not dramatically. Our 2005 Acura MDX really sucks fuel in the winter, and can average as low as about 16 mpg on a tank, or as high as about 19 mpg in town (on premium, too!). On the road, it returns about 22 mpg.
Over time, our MDX has seemed to lose some fuel economy. When we bought it with 58k miles, it was closer to upper teens all the time in town and 23-25 mpg on the road. Now with 120k miles, it seems to be off 5-10%.