A specified toe in or toe out setting is dependent in part on the scrub radius. If the scrub radius is positive or inside of the tire centerline, like most rear wheel drive cars, you need toein.
A front wheel drive vehicle usually has 0 to negative scrub radius and this calls for a toe-out setting.
Like you were thinking Gary, If you change the wheel offset/width relationship or even the tire diameter, the scrub radius may change.
Excessive changes in camber will also alter the SAI and affect the scub radius.
The purpose of static toe-in is to prevent a dynamic toe-out.....and visa-versa.............
JD