Okay, while I realize you must have much more knowledge about tires than I do (which I think is obvoiusly needed here), I will ask some questions of a few of your statements.
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1) The footprint that gives best wear is not the same as the footprint that gives best durability. Optimizing for wear results in a lower inflation pressure, which is the wrong way for durability.
This one seems to be contradicting itself. What is the difference between maximum tread life and durability?
durable: Capable of withstanding wear and tear or decay
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2) Inflation pressure and tire size = load carrying capacity. So the tire loads have to be considered when you start trying to change tire size. When inflation pressures are specified by vehicle manufacturers, the actual loading of the tire is just the one of the considerations, albeit the most important one. Most vehicle manufacturers have some reserve capacity built into the specification. (An old professor of mine used to say "Overdesign - Underutilize!". Good advice.) If one is going to change tire size, you have to maintain the reserve capacity the vehicle manufacturer was using.
Okay, I agree with how this starts in regards to tire size, inflation pressures and load range of the tire. However, "Overdesign - Underutilize" means one thing to me, and it should mean the same to any engineer - wasteful. Why should I overinflate my tires everyday just so they're ready when I do place a heavy load on them?
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3) There are quite a few factors beyond load and inflation pressure that affect the footprint. One of the largest ones is rim width. I'll bet medic has a Ford F-150 with P235/70R16's which came with 7" wheels - the design rim wdth. (Please note the P, not LT) However an LT265/75R16 has a design rim width of 7 1/2. The narrower width forces the tread to "arch" a little bit, which changes the footprint in the wrong direction - toward lower load capacity.
Never did I advocate anybody changing the tire size recommended by the vehicle manufacturer. In fact I recommended agaist it, stating that engineers designed these specs, and most of us know nothing about engineering. Therefore, we should follow the specs provided by the vehicle manufacturer. Do as I say, not as I do kinda thing
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5) Tires are held onto the rims with both a mechanical action (sfaety humps) as well as the inflation pressure. By far the greatest force is the inflation pressure. For this reason I always recommend that 25 psi be the lowest pressure used in a P metric tire in order to prevent the bead from dislodging during emergency manuevers. (Point of reference - The government's preferred test for rollover characertistics of SUV's is a "Fishook test", which sometimes results in the tire coming off the rim - so tubes are part of the test specification.)
As I stated, I have been running my rear tires at this low PSI for over 100k miles. In that time I have had to make some emergency manuvers and was quite impressed that I didn't roll the truck over during one of these events. If the tires didn't pop off the bead with the force of a sudden directional change at 75 mph, I doubt I have anything to worry about. Please keep in mind that this was not a high speed lane change, it was an evasive manuver.
So, once again, with passenger cars, I recommend following the vehicle manufacturers recommendations. With pickups, I maintain that, unless carrying a load, the specified rear tire pressure is too high. This pressure owuld include that reserve that you are talking about. In certain circustances, this overpressurization can cause the rear tires to bounce and lose contact with the road. In your words, not a particularly predictable situation.
Here is a decent chart regarding tire size, load, & inflation. Unfortunatly, it only includes a few different size tires.
http://www.michelintruck.com/michelintruck/pdf/rv_load_inflation.pdf