It seems to me that most cars/trucks these days come with either an OLM or a specific OCI such as 3,5,7,10 thousand miles - whatever. There are very few of these vehicles that have OLMs calibrated for synthetic oil. Except for things like 'Vets and a few Euros, they are calibrated for dino. And for those without OLMs, the owner's manual OCIs based on mileage/time factors are also almost always for dino use, not synthetic.
I understand there may be certain very severe conditions or useage that might stress regular oil too much for the intervals suggested by the car makers. Usually, the OLM will track such conditons and/or the manual will specify different OCIs for listed factors that are considered "severe". But unless those conditions are present, why not use the weight and type oil the manufacturer recommends and change the oil out per the instructions? You sure won't run into any warranty problems this way.
I see no real reason for synthetic oil unless a vehicle is truly in "severe" use or you just want to extend drains beyond the recommended OCIs. And by "severe" use I mean things like constant, heavy towing that impacts on engine load, living in the North Pole and driving two miles to work each day - that sort of thing. Driving in normal conditions the today's top brand dino oil should do just fine. Checking things out now and then with a UOA is always a good idea to be sure the OLM is not lying to you or to see if you need to shorten (or possibly increase) the recommended change interval. Bottom line is if dino packs keep advancing as they have been, I see no future for synthetics beyond a rather limited client base.