There are a number of ELC(Extended Life Coolant) coolants for truck use on the market. Shell has a Rotella product, Chevron a Delo product, and so on.
These should be installed and maintained according to their manufacturer's directions.
For example, Shell has a test kit to determine whether the the existing coolant can be converted or whether you need to completely drain and refill. Shell also provides detailed instructions on testing and maintaining the coolant.
These products are aimed at the large diesel engine market. In the United States it would be unusual to find them in a FWD vehicle or automobile.
All of them contain nitrites.
Based on testing you determine when the coolant needs chemical replenishment, and that's done using an "extender".
If you have one of these in your Isuzu, it might be worthwhile to have a truck garage which sells Texaco test the coolant and see if it can be extended. Commercial fleets have the equipment for whatever brand they're using and do their own testing.
With conventional coolants replenishment of additives is accomplished with an SCA, supplemental coolant additive. This can be introduced into the coolant a number of ways, the most common being a filter that leeches a small amount of SCA into the coolant over time.
Typically an SCA contains these kinds of chemicals:
Nitrite: provides protection against cavitation erosion, and inhibits corrosion.
Borate: prevents acidity.
Nitrate: protects aluminum and solder.
MBT (Mercaptabenzothiazole): coats copper and copper alloys, protects them from direct contact with coolant and dissolved oxygen.
Since you've got a diesel you really want a product containing nitrite. Other than that, each of the types has its own advantages. The trend in the U.S. is towards extended life coolants.
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