Back in the late '90s I had a new motorcycle and an old early '80s car. I ran castrol Edge 10W-60 full synthetic in the bike and castrol GTX 20W-50 mineral oil in the car.
The bike only needed about 4 L for an oil change, and I always cracked a fresh 5L jug for the bike. I stored up all the extra litres of synthetic and every 4th or 5th oil change on my car, I gave it a sump of synthetic 10W-60 instead of the usual 20W-50 mineral.
There was absolutely no problem going back and forth between synthetic & mineral on my old 80s car. I was the second or third owner of the car, and I feel confident that it lived on mineral oil only before I got it. Again, no leaks and no consumption when I switched to the synthetic, and no problem when it went back to the mineral for the next few OCI.
Did, I notice any difference? Yes, on the synthetic the car started smoother and with less noise in winter, plus the oil stay a lot cleaner looking for longer with the synthetic. I would have run the car on synthetic 100% of the time, except the car was a bit of a beater and I couldn't justify the extra cost of the synthetic, no other reason.