I'm #2. A couple years ago, when LOTS of gas stations had their bathrooms "closed due to health concerns," I bought a little bottle meant for camping to relieve oneself without getting out of a sleeping bag. I carry food with me and eat with one hand, pour coffee with one hand, etc., the ONLY thing I stop for is gas, and then it MAY be 72 seconds every 3 states.
Of course, all that is just me; if I'm with the wife & family, there's always the Complaint Dept: I gotta pee. I'm hot, turn the AC on. I'm cold, turn the heat on. I'm hungry. I'm tired. Are we there yet? How many more hours? Are we going to stop before midnight? I want a Hotel.