I've certainly "experimented" with various weights, not sure if it helped or hurt anything, so in my opinion it should be fine. I will say this though...I take my engines to the "distance"...300k if I can. That's lonely territory. My 1999 Honda Accord with the (I can't even remember what engine it was...2.4?Vtec?). That engine was starting to consume quite a bit of oil before I sold it at 289,000 miles. Steady diet of 5w30 Super Tech conventional, 3,000 mile intervals. With a lot of "special brews" in between...different weights, different brands, sometimes all at once, but always 3k mile intervals. The thing was consuming a quart every 500 miles it's last year with me.
My other strange brew car was a 2007 Lexus LS460. Only a synthetic diet, 5w20 Mobil1, then TGMO, then Carquest synthetic, Napa Synthetic, Castrol Manetic. I started blending 5w20 with 5w30 because it started consuming oil at around 130,000 miles...by 178,000 miles it was consuming a quart every 1,000. I for the most part only ran 5,000 mile intervals, but I did try 7,500 mile intervals for a year (because everyone on the forums were saying Toyota went to 10k intervals and the LS460 was included).